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Home » A Head-to-Head Comparison: Alka Seltzer Cold And Flu vs. Z-Flu

A Head-to-Head Comparison: Alka Seltzer Cold And Flu vs. Z-Flu

A Head-to-Head Comparison: Alka Seltzer Cold And Flu vs. Z-Flu

If you’re looking for relief from cold and flu symptoms, you can choose from various over-the-counter options. Two popular choices are Alka Seltzer Cold and Flu and Z-Flu. While Alka Seltzer Plus has a long-standing reputation, Z-Flu offers a unique formulation with organic ingredients and immune support. 

In this comparison, we will explore the features, ingredients, benefits, availability, and comparison of these two cold and flu medications. In order to make an informed decision, I am here to assist you in choosing the best option that may suit you best. 

What is Alka Seltzer Cold and Flu?

Alka-Seltzer Cold is a well-known and popular over-the-counter medication used to relieve symptoms associated with the common cold and flu. It is manufactured and marketed by Bayer, a trusted and reputable pharmaceutical company with a long-standing history.

Alka Seltzer Cold and Flu is widely recognized for its effervescent tablets, which quickly dissolve in water to create a fizzy solution. This unique delivery method allows for fast absorption of the medication, providing rapid relief for cold and flu symptoms.

The brand has built a strong reputation over the years thanks to its effective formula and availability in pharmacies and retail stores. Many individuals turn to Alka-Seltzer Cold and Flu as a trusted option for alleviating symptoms such as cough, runny nose, sneezing, nasal and sinus congestion, minor aches and pains, and headaches. 

Alka Seltzer Cold and Flu Ingredients

Here is a list of the ingredients in Alka Seltzer Cold and Flu and alka seltzer day and night.

Alka Seltzer Cold and Flu Day:

  • Acetaminophen: It is an effective pain reliever and fever reducer. Acetaminophen helps alleviate headaches, body aches, and fever associated with cold and flu symptoms.
  • Dextromethorphan hydrobromide: Dextromethorphan is a cough suppressant. It helps to reduce coughing and soothe the throat irritation caused by colds and flu.
  • Phenylephrine hydrochloride: Phenylephrine is a decongestant that helps to alleviate nasal congestion by shrinking blood vessels in the nasal passages.

Alka Seltzer Night

  • Acetaminophen: Similar ingredients found in day form. Acetaminophen in Alka Seltzer Cold and Flu Night helps reduce pain, fever, and headache associated with cold and flu symptoms.
  • Chlorpheniramine Meleate: This compound basically used for alleviating allergy symptoms. 
  • Dextromethorphan hydrobromide: Dextromethorphan is a medication that helps suppress cough and soothe the throat, relieving coughing.
  • Doxylamine succinate: It is an antihistamine with sedative effects. It helps relieve sneezing, runny nose, and nasal congestion.
  • Phenylephrine hydrochloride: Phenylephrine acts as a decongestant, relieving nasal congestion by reducing swelling in the nasal passages.

Comparing the two formulations, the primary difference lies in the absence of doxylamine-succinate in Alka Seltzer Cold and Flu day versions. Doxylamine succinate is an antihistamine with sedative properties that can help with sleep during illness.


Z-Flu is a cold and flu medication that provides an alternative option for relieving symptoms associated with these common illnesses related to the common cold. While not as widely known as Alka-Seltzer Cold and Flu, Z-Flu has gained attention for its unique formulation and effectiveness. 

Z-Flu is invented by Dr. Vladimir Zelenko a Nobel nominee. During the COVID-19 pandemic, he gained fame for his revolutionary Zelenko Protocol, which saved thousands of American lives. Z-Flu gummies are manufactured by his company named, Zelenko Lab LLC.

Z-Flu is specifically formulated to target the symptoms of cold and flu, offering relief from nasal congestion, cough, common cold, cough, sore throat, headache, and body aches. It is designed to help individuals manage their symptoms and feel more comfortable during their recovery process. This supplement also additionally gives immune support. 

To learn more about Zflu, read this article: Easy Mucus Relief: Causes, Symptoms and Natural Remedies

Ingredients of Z-Flu

Quercetin: It is known for its antioxidant and anti-inflammatory properties and is believed to have immune-boosting effects.

Zinc: The mineral Zinc is vital for maintaining optimal immune function. Its participation in various enzymatic reactions helps to sustain the integrity of the immune system.

Vitamin C: A soluble vitamin is known as ascorbic acid. It is also known for its immune-boosting properties, and it is also a well-known source of antioxidants. It serves as an antioxidant and plays a crucial role in various immune functions.

Vitamin D: It is an vital vitamin that helps regulate the immune system. Our bodies can make it when we’re in the sun, and we can also get it from certain foods. If we don’t have enough vitamin D, it can affect how well our immune system works.

Elderberry extract: Elderberry extract comes from the berries of the elderberry plant, colds and flu are often treated with this natural remedy. Elderberry is believed to possess antiviral and immune-enhancing properties.

Alka Seltzer Cold and Flu vs Z-Flu 

FeaturesAlka-Seltzer Cold and FluZ-Flu
PurposeRunny nose, sneezing, cough, nasal and sinus congestion, minor aches and pains, and headachesCommon cold, fever, headaches, cough, reduced sinus infection, and immune support
IngredientsDAY – Dextromethorphan-hydrobromide AcetaminophenPhenylephrine bitartrateChlorpheniraminePhenylephrine-hydrochloride 
NIGHT – Acetaminophen Doxylamine succinateDextromethorphan- hydrobromide Phenylephrine-hydrochloride
QuercetinZinc77 Vitamin CVitamin DElderberry extract
OTC (over-the-counter med)YesYes
DosageDaily 2-3Daily 2 gummies 
BenefitsReduce cold and flu Cough reliefProtect from the common coldImmune boosterAssisting in the prevention of respiratory illnessesMade from organic ingredients 
FormGel, Pill, Fizz (dissolved in water)Gummies
Side effectsDizziness, nausea, stomach upsetDry mouth (rare)
InteractionsPhenelzine, and Moclobemide. It may interact with muscle relaxant medication like metaxalone.Rare
AvailabilityAvailable anywhereOfficial website (Manufactured by Zelenko Lab LLC)
Medication variationDay/ NightBoth day and night 
Third-party lab tasted No Yes
Kosher CertifiedNo Yes
Manufactured in GMP facilityNo Yes


Alka-Seltzer Cold and Flu and Z-Flu both offer relief for cold and flu symptoms. Alka-Seltzer provides rapid relief with effervescent tablets, while Z-Flu includes organic ingredients for immune support. The choice between these two medications depends on individual preferences and needs. 

Finally, Alka-Seltzer Cold and Flu is widely available and trusted, while Z-Flu offers a natural approach to reducing common cold symptoms with immune support. Consider ingredients, dosage, and interactions before choosing. Consult a healthcare professional for guidance.

Frequently Asked Questions   

Q: Can I use Z-Flu for children? 

Ans: Zelenko Z-flu is not recommended for individuals under 18 years old. However, there is a supplement specifically designed for children the ages betwee of 3 and 18 called Kids Z-stack.

Q: Can I use Alka-Seltzer Cold and Flu for children? 

Ans: Alka-Seltzer Cold and Flu is not recommended for children under the age of 12.

Q: How long does alka seltzer work? 

Ans: Alka-Seltzer is known for its fast-acting relief, and many users experience relief within 20 to 30 minutes after taking the medication.

Q: What does alka seltzer do?

Ans: It’s an over-the-counter medication that provides relief from common cold and flu symptoms. 

Q: Can I take Alka-Seltzer for Cold and Flu with other medications? 

Ans: Consult a doctor before taking Alka-Seltzer Cold and Flu if you are taking other medications.

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